Sentence examples for generalized toxicity from inspiring English sources
Very high doses of MO, which may have generated more extreme downregulation of endogenous Ofd1, were associated with a generalized toxicity, precluding further analyses of the KV.
However, investigating the effects of injected toxicants to species other then medaka is important to develop more generalized toxicity levels.
Our vaccines were produced under GMP conditions, free of contaminants including lipopolysaccharide, and nasal testing in rabbits, including detailed CNS histology, revealed no localized or generalized toxicity.
As non-specificity and toxicity are a major drawback with conventional chemotherapeutics, we proposed to discover novel agents acting primarily through the caspase-8 axis as opposed to generalized toxicity.
Thus, our model system truly allows identification of TRAIL-sensitizing agents acting selectively via the caspase-8 apoptotic axis, as re-expression of the protein alone has no effect on generalized toxicity.
Thus, the effects observed are not a reflection in any sense of a generalized toxicity.
However, this may lead to generalized systemic toxicity, particularly evident for acute liver toxicity induced by Fas-specific reagents.
Two participants switched due to NVP toxicity (generalized rash and unspecified toxicity) and one due to interaction with anti-TB medications.
It has been proposed that IV iron leads to hypophosphatemia by direct proximal tubular damage, resulting in a specific decrease in tubular phosphate reabsorption, but without other manifestations of a generalized proximal tubular toxicity, such as glucosuria or aminoaciduria [ 16].
It is unlikely that the unresponsiveness observed in these groups is due to a generalized PRN-induced toxicity to the exposed CTLs because the viable cell yield of the 1° EtOH-treated/165-μM PRN group is approximately 70% of the EtOH-treated group, and that of the 1° EtOH-treated/2° 66-μM effectors is approximately 90% that of the EtOH-treated group.
Only one patient developed Grade 3 skin toxicity with generalized erythroderma and disfigurement of the face requiring dose reduction.
