Eleven (69%) survivors and 2 (18%) nonsurvivors had only localized skin or limb symptoms (i.e., pain, swelling, erythema, exudate); 5 (31%) survivors and 4 (36%) nonsurvivors had both localized and generalized symptoms (i.e., fever, confusion, seizures, abdominal pain, fatigue, malaise, sweating, headache), and 0 survivors and 5 (45%) nonsurvivors had only generalized symptom (Table 1).
In fact, so-called monoclonal antibodies frequently produce severe generalized symptoms like aches and chills, though their use is justified by the enormous potential benefit.
Other generalized symptoms include fever, sore throat, enlargement of the lymph nodes, and headaches.
Both local and generalized symptoms subside, only to reappear again in a few days; periods of fever may then alternate with afebrile periods.
Diphtheria, acute infectious disease caused by the bacillus Corynebacterium diphtheriae and characterized by a primary lesion, usually in the upper respiratory tract, and more generalized symptoms resulting from the spread of the bacterial toxin throughout the body.
There were only mild generalized symptoms, with elevation of body temperature to 38.1°C.
Some generalized symptoms include fever, fatigue, weight loss or loss of appetite, shortness of breath, anemia, easy bruising or bleeding, petechiae (flat, pin-head sized spots under the skin caused by bleeding), bone and joint pain, and persistent or frequent infections.
These 'solicited symptoms' (local symptoms: pain, swelling; generalized symptoms: drowsiness, fever, irritability, loss of appetite) were graded and recorded on diary cards.
Although animals did not develop lesions as seen in human MPX infections, localized signs were apparent with the foot pad route of inoculation, primarily in the form of edema at the site of inoculation; while the Congo Basin intranasal route of infection led to generalized symptoms, primarily weight loss.
Remission and absence of generalized symptoms were favorable factors for HRQOL in MG patients.
Rates of progression of ocular MG to generalized symptoms were reported as being 49%-69 49%-69 46].
