Exact(6)
In addition to our own data, Takamura et al. showed that renal 123I mIBG scintigraphy was associated with measurements of muscle sympathetic nerve activity (as a measure of generalized sympathetic outflow) in patients with primary hypertension [18].
And is fibromyalgia a generalized sympathetic dystrophy?
Fibromyalgia could be a generalized sympathetic dystrophy since both conditions are activated by trauma and partly linked to sympathetic mechanisms.
First, PD is associated with generalized sympathetic denervation (38, 39), a condition that appears to contribute to reduced metabolic activity within adipose tissue and to an improved cardiometabolic profile (15, 40).
Activation of autonomic centers in the dorsal hypothalamus causes a generalized sympathetic response that includes activation of the heart (increased heart rate and cardiac output) and increased vascular resistance in the viscera, which increases the perfusion pressure of tissues, especially the muscles, heart, and brain.
One neuropathological hallmark of PD is generalized sympathetic denervation, which is known to be present even in patients without clinically evident autonomic failure [ 88].
Similar(54)
We therefore proposed that FM is a generalized form of reflex sympathetic dystrophy [ 33].
Our results suggest that chemical sympathectomy caused by reserpine administered s.c. produces a generalized and prolonged decrease in peripheral sympathetic activity that could be compensated by an increase in activity of the adrenal gland.
As observed in exercise, increased metabolic activity of muscles, including respiratory muscles, leads to increased afferent nerve activity, which increases sympathetic activity and produces generalized vasoconstriction in areas of nonworking muscle [ 18, 49, 50].
The primary theoretical benefit would be sustained reduction of blood pressure, brought about by disruption of primary sympathetic output, without leading to the generalized adverse effects of broader sympathetic disruption.
In our case, the presence of sympathetic nervous system tumor represented further clinical evidence of generalized autonomic nervous system dysregulation; 5 10% of CCHS cases have a neurocristopathy [6].
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