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This supports an influence of serotonin on motor neuron generation, but not a generalized effect on spinal neurogenesis.
These results are not due to a more generalized effect on basal dendrite branching, as Sholl analysis demonstrated no significant changes in dendritic arbor complexity between control and experimental conditions (data not shown).
Given the links between paternal age, neurodevelopomental disorders, and immune function, it seems that paternal age might also have a more generalized effect on immune function as it was found to have on neurodevelopment.
If the viability of the skin is compromised, this will have a generalized effect on its metabolic state.
It is unknown, therefore, whether temperature may have a more generalized effect on the starvation response of L. hongkongensis.
It therefore seems unlikely that the activation of JNK signalling is due to a generalized effect on ligand receptor complex trafficking or degradation.
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Thus, the HCV-induced suppression of TLR9-mediated IFN-α secretion is not due to a generalized effect of HCV on TLR signaling in pDCs.
Interestingly, under these conditions, RelA mRNA levels remained unchanged, suggesting that the Tat-mediated increase in RelB was not a generalized effect of Tat on NF-κB subunits (Figure 1).
Phenotypic variability in the sample suggested a generalized effect of hypoxia on craniofacial morphology; thus, the possibility of a cellular metabolic stress response to hypoxia was addressed.
A more generalized effect of paternal age on immune function seems plausible.
These data are consistent with the view that the mitogen for OPCs in AEF is specific and not due to a generalized effect of any membrane fraction on OPCs.
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