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Many of those who survive long years of alcoholism show a generalized deterioration of the brain, muscles, endocrine system, and vital organs, giving an impression of premature old age.
Five control animals were euthanized during the treatment period and one control animal was euthanized during the recovery period due to generalized deterioration of the animals' health status.
One of the most striking changes that occur during normal human aging is immunosenescence, a pro-gressive and generalized deterioration of immune functions that affects all cells and organs of the innate and adaptive immune systems.
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The fact that after just one or two generations hatchery fish perform better than wild fish in hatchery environments (Reisenbichler et al. 2004) also points to positive selection, rather than to some generalized genomic deterioration (relaxation of purifying selection).
The generalized time proportional deterioration and partial backlogging rates are used in model formulation.
Induced hyperammonemia using either glutamine alone [ 22] or combined with other amino acids [ 30] is associated with electroencephalographic, brain magnetic resonance and biochemical alterations, the neuropsychological consequences of which are inconstant, showing either absent [ 31], partial [ 22] or generalized [ 32] deterioration of tests' performance.
Hung ([2011]) gave an inventory model with generalized-type demand, deterioration, and backorder rates.
After one month of anti-tuberculosis treatment, he presented with acute generalized weakness and rapid neurological deterioration.
Giri et al. (1996) considered a generalized EOQ model for deteriorating items here in which the demand rate, deterioration rate, holding cost and ordering cost are all assumed to be continuous functions of time.
In studies aimed to identify the relationship between presence of cerebrovascular disorders and prevalence of cognitive disorders in the general population, signs of vascular pathogenesis such as arterial stiffness or generalized atherosclerosis are consistently related to cognitive deterioration which ranges from mild severity to dementia (Hanon et al 2005; Vinkers et al 2005).
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