Sentence examples for generalized defect from inspiring English sources

It is also significant that epididymal fat showed a similar pattern (Figure 3) suggesting a generalized defect in adipose development.

Again, this did not reflect a generalized defect in cellular calcium handling since TCR engagement induced comparable Ca2+ signaling in purified CD83Tg and wild-type T cells.

The analysis of cytokines in the culture supernatant revealed increased IL-10 secretinn in LPS activated CD83Tg spleen cell cultures compared to wild-type spleen cell cultures (figure 3D), arguing against a generalized defect in CD83Tg lymphocytes.

Next, to determine if the reduced ability of SP thymocytes to produce TNF was due to a generalized defect in their activation, we examined the expression of activation markers CD25, CD69, CD44 and CD62L on the P14-CD8+ SP thymocytes and splenic T cells.

However, previous work has demonstrated that self-reactive T-cell cells assisting autoantibody production in NZB/W mice do not result from a generalized defect in T-cell tolerance, and that thymic and peripheral tolerance to most self-antigens are intact in NZB/W mice [18].

Comparison of CTCF occupancy at the MYC locus, and at another CTCF binding site at the APBA1 (Amyloid beta A4 precursor protein-binding family A member 1) locus on chromosome 9q, in FRDA versus normal cell lines did not show a similar reduction, indicating that FRDA cells do not have a generalized defect of CTCF binding (Fig. S1).

The attempt to use higher MOs concentrations resulted in acute generalized defects that impeded additional analysis of the morphants, as previously reported for the single prox1a MO injection [10].

Maternal diabetes has been shown to induce generalized defects in CNCC development in some, presumably genetically predisposed, individuals among the offspring [ 17].

A HIGM picture can also be seen as part of generalized defects of DNA repair and in antibody deficiency syndromes, such as common variable immunodeficiency.

Such deficit could reflect a secondary effect of the developmental abnormalities of SST+ interneurons observed in these mutants, an idea which is supported by the emerging view that abnormal maturation of specific subsets of GABAergic interneurons in the cortex often lead to generalized defects of other subpopulations of interneurons across the entire neuronal network (Cossart, 2011).

The defective repair is most likely lesion-specific rather than a generalized BER defect since HCC1937 nuclear extracts repaired uracil at levels comparable to AG11134 extracts (Fig. 2 panels A-D).