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Generalized cells respond to several types of molecules.
For example, coelenterates have well-defined nerve nets, and their contractile fibres, although only specialized parts of more generalized cells, are organized into discrete muscle units.
The generalized method of cell (GMC) micromechanical model originally proposed by Paley and Aboudi [Paley M, Aboudi J. Micromechanical analysis of composites by the generalized cells model. Mech Mater 1992; 14(2):127–39] was extended to include the thermal mechanical behavior, from which the thermal residual stress within the fiber and matrix phases was calculated.
Thus our Generalized Cells represent tumor-cell clusters, describing the averaged behavior of many cells.
To simulate more realistic tumors without needing to treat cluster of cells as single generalized cells, we are investigating parallel computation techniques.
In our simulation, Generalized Cells are spatially-extended domains, which represent either tumor cells or non-tumor tissue and reside on a single 3D, square Cell Lattice [4], [97].
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It is composed mostly of storage parenchyma cells (a relatively generalized cell type).
A more generalized cell-based research flourished as grid-based coverage techniques, in which environment was divided into a set of uniform grid cells.
This paper extends the previously developed generalized cell maping method based upon the short-time Gaussian approximation (GCM/STGA) to systems with dry friction damping.
The results obtained by the generalized cell mapping method are found to be in good agreement with those obtained by direct simulation.
In obtaining the global information of first-passage time probability of the system, there are large computational advantages of the generalized cell mapping method over direct Monte Carlo simulation.
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