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We show the generality of the procedure by computing supports for a variety of parts in both two and three dimensions, including a complex model of the mascot of the University of Wisconsin-Madison.
With the optimal reaction conditions in hand, we started to investigate the generality of the procedure in terms of different substrates.
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The generality of this procedure was evaluated by the reactions of various benzoyl chlorides with 2-amino-3-hydroxypyridine. As shown in Table 3, in the most cases, 2-amino-3-hydroxypyridine completely reacted with a wide range of substituted benzoyl chlorides and afforded the corresponding 2-aryloxazolo[4,5-b]pyridines in good to excellent yields.
It also demonstrates the generality of the NEM procedure for generating small molecule bound conformations.
To test the generality of the NEM procedure for generating bound conformations, the validation study with crystal structure AJUXUY was repeated with 21 additional small molecule complex crystal structures (Table 2).
In addition, two drugs (amphetamine and sodium salicylate) will be investigated to support the generality of the testing procedures.
The main attribute of this procedure is its generality: the procedure is applicable to any kind of structure and does not require heavy coding.
In particular, without loss of generality of the applicability of the proposed procedure, the Park and Ang local damage index, its modified variant presented by Kunnath, Reinhorn and Lobo; the Chung, Meyer and Shinozuka local damage index; along with the maximum and final softening damage indices proposed by DiPasquale and Çakmak, are calibrated on the basis of the width of crack openings.
The VLE-fit procedure performs as well as the LLE-fit procedure, indicating the generality of the model.
To establish the generality of the sensitivity to hypotonic stress, the same experimental procedure was repeated using KCl and sorbitol (Fig. 2B).
The ADtree algorithm was used to identify markers for classification of tissues and a cross-validation procedure was used to test the generality of the identified miRNA-based classifiers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com