To test the generality of the observed hierarchy between the synonymous variants of sinR, we generated an additional set of eleven sinR synonymous variants in which we replaced either three TCC codons or two AGC/AGT codons with their synonymous counterparts.
Importantly, we have demonstrated similar kinetics for 2 different cancer cell lines with 2 different reporters (F-luc and SEAP) thus validating the generality of the observed results.
The new complex confirms the generality of the previously observed bipartite arrangement.
The data also confirmed the generality of the results observed in the two study sites.
To determine the generality of the patterns observed with the K562 samples, the same analysis was repeated with liver RNA (Table 3).
In addition, the generality of the phenomenon observed in this model implies that other types of negative ecological interactions will likely produce the same positive results on species persistence times.
However, there were some concerns about the interpretation and generality of the asymmetry observed in the crystal structure, and about the ATP hydrolysis experiments, as well as numerous suggestions on discussion of results from other groups on other systems.
We explored the impacts of herbicide cycling on the rate of resistance evolution, the level of resistance selected, the cost of resistance and the degree of generality (cross-resistance) observed.
One such generality, also observed in India, was the phenomenon of two distinct epidemic waves, a mild one in the spring or summer of 1918, and a second and much more lethal one in the autumn or winter [ 8].
However, in providing the first evidence for age-related differences in T-cell subsets and acute phase proteins in a mammal experiencing ecologically realistic conditions, our data do suggest an important new degree of generality for patterns observed in the laboratory by immunologists.
