Clinical symptoms from the genital tract such as purulent vaginal discharge are often accompanied by generalised signs of disease such as depression, polyuria, polydipsia, lethargy, fever and gastro-intestinal disturbances [ 3].
If skin symptoms occur, consultation with an experienced travel medicine clinician should be considered as a matter of urgency, in order to reduce the high fatality rate if generalised signs of HAT develop.
For each positive culture result, the type of isolated organism, number of positive culture sites, time to culture positivity, the presence of focal or generalised clinical signs of infection and an overall assessment of illness were recorded.
Two animals (Nos 10, 9) were euthanized on days 1 and 3 post-challenge, respectively, due to generalised severe disease signs, including severe dyspnea.
But, the latter two Swiss studies did not distinguish between (primary) generalised epileptic seizures and focal epileptic seizures evolving into generalised seizures; and preictal signs were reported in a substantial number of dogs (which were not considered as part/onset of a seizure), which may explain the discrepancy to the seizure type found in the Danish study.
Tissue specimens from macro- and microscopically normal terminal ileum were obtained from patients (eight women and one man, median age 69 (range 36 91) years) who were undergoing surgery for colonic cancer (N=3) or surveillance colonoscopy for colonic polyps (N=6); The colon cancer patients had no signs of generalised disease and none had received preoperative chemo- or radiotherapy.
In addition, four animals in the pre-1975 group displayed signs suggestive of generalised seizures.
Aborted pups are partially autolysed and show signs of a generalised bacterial infection, such as subcutaneous oedema, abdominal hemorrhages, and degenerative lesions in liver, kidneys, spleen and intestines.
In a 2012 paper, physical therapist Mark C Scheper of Amsterdam's University of Applied Sciences explicitly asked whether generalised joint hypermobility was "a sign of talent or vulnerability" for professional dancers.
The main objective clinical findings are generalised wheezing (the most common sign), crackles, decreased lung sounds, clubbing, and cyanosis.
There were three things to welcome in the data for the final three months of 2013: the increase in activity was slightly higher than forecast, it was a generalised pickup, and there were tentative signs of a recovery in investment.
