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Dispositional optimism, defined as generalised outcome expectancies that good things, rather than bad things will happen, was measured using the short version of the Life Orientation Test (LOT) (Scheier and Carver, 1987) (scale range 0 32).
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Optimists benefit from expecting positive generalised outcomes 1 and from explaining bad events with external, unstable and specific causes 2 in terms of health.
Establishing whether this pattern is generalised or health outcome-specific will further understandings of the aetiology of gender differences in health.
A linear mixed effects model will be used to compare the intervention and usual care periods for continuous outcomes and generalised linear mixed effects model for binary outcomes.
Data will be analysed according to the intention-to-treat principle, using a linear mixed model for continuous outcomes and a generalised mixed model for dichotomous outcomes.
Longitudinal analyses will be performed using general (interval-scaled outcome) or generalised (binary or ordered categorical outcome) linear mixed models.
Owing to the possibility of organ-specific functions of EGF signalling in promoting metastasis, clinical trials should measure both generalised and organ-specific outcome of metastasis.
This is a generalised linear model with outcome d ki with a Poisson error structure and a link function ln(μ ki −d ki *) with offset ln y ki ).
For comparison of levels of hsTnT and NTproBNP over time between patients with poor and good outcome, a generalised linear mixed model with gamma regression was used due to non-normal distribution of hsTnT and NTproBNP.
Intervention and usual care periods will be compared using a linear mixed effects model for continuous outcomes and a generalised linear mixed effects model for binary outcomes.
Survival analysis techniques will be used by using Cox analysis for binary outcomes and generalised models for continuous variables.
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