Sentence examples for generalised defect from inspiring English sources

The absence of a C4BP effect in cells from patients with CD40 mutations is more difficult to reconcile with our data, although it is possible that the mutation caused a more generalised defect rendering cells unresponsive to TNFr mediated stimuli.

9 We hypothesise that because of receptor redundancy a generalised defect in adhesion due to 77H is unlikely to be an important pathogenic mechanism in SLE.

Further work would be needed to deduce the effects of this mutation, but the possibility of generalised defects in the control of gene expression cannot be ruled out.

Generalised defects of the dental hard tissues of systemic origin can occur prenatally, perinatally, postnatally, during infancy, or during early childhood.

In conclusion, the application of quantitative CGI methylation profiling, together with multinomial logistic regression modelling, demonstrates a role for CGI methylation as a feature of a generalised colorectal mucosal field defect associated with the presence of a neoplastic lesion.

Our findings are consistent with this hypothesis, suggesting the occurrence of a generalised dysfunction of TLR signalling rather than a defect in a specific receptor pathway.

Humphrey visual field perimetry using SITA standard algorithm in the right eye confirmed the superior field defect, as well as a more generalised depression more prominent in the right superior field.

The resultant defect is not specific to the generalised environmental insult but depends, as with localised defects, on the timing, severity and duration of the insult, the stage of development of the dentition and the host's susceptibility; the same insult results in different responses in different individuals.

The developmental mechanism in humans with ENAM mutations associated with localised pitted hypoplastic defects probably differs from that causing generalised hypoplasia in the Enam null mice.

p53 hyperactivation in these mice is accompanied by a ∼20% shorter median lifespan and the premature appearance of several age-related phenotypes, including osteoporosis, kyphosis, generalised organ atrophy, impaired wound healing, hair re-growth defects and slowed recovery following myeloablation.

16 Although the contact lens occluder causes a generalised reduction in sensitivity, it does not cause a localised defect characteristic of an absolute central scotoma.