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Crucially for the retroactive generalisation issue, however, discriminative extinction learning in context A did not generalise retroactively to attenuate renewal of a previously established response trained in that context (Todd, 2013, experiment 4; Troisi, LeMay, & Järbe, 2010).
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Thus, producing overall consensus on these experiences creates the potential problem of providing a 'bland generalisation' of the issues [ 22] and masking individual differences, to provide an unrealistic averaging of beliefs [ 23].
The issue of generalisation brings us to some other methodological considerations.
Clinical trials will never provide all the answers, particularly since their study groups are restricted with inclusion and exclusion criteria; therefore generalisation is always an issue [ 2].
A final issue is generalisation, which may be limited by the focus on French GPs, but has the potential to have a broader focus than in France or in general practice.
The small size of the sample raises concerns of type II error and the inclusion of only one PCC raises issues of generalisation of other primary care settings.
However, it demands manual outlining of endocardial contour, which needs an additional 4 to 11 minutes [ 18], a practical issue limiting its generalisation.
It is important to remember that the generalisation of the result from a case study is a theoretical generalisation and not a statistical generalisation (24, 26).
Some methodological issues question the generalisation of the results.
This issue might limit the generalisation of the review findings.
A third issue potentially limiting the generalisation of our findings is the participation rate of around 70%.
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