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In general, suppression by Tregs is mediated by cell-cell contact and production of suppressive cytokines.
Herbivory resulted in a general suppression of growth of H. verticillata in all pots.
In 1207 it was burnt to the ground; in 1538 it was shut down during a general suppression of monasteries, and in 1862, the South Eastern Railway decided to run a new line through the hospital grounds.
On the suspicion that the initial delayed recovery might be due to a general suppression of rod-action on the part of the cones the experiment was repeated with a cone-blind woman.
CpG-52364 was designed to interfere at an early stage of the immune cascade by blocking the inappropriate immune activation of all the three TLRs and to treat the underlying cause of the disease without causing general suppression of immune function.
Quantification of aflatoxin B1 concentrations (Fig. 2 suggested general suppression of aflatoxin synthesis in the presence of nC60.
Gene expression profiling revealed a general suppression of pro-apoptotic machinery, such as Apaf-1 and caspase 3, and sustained levels of pro-survival factors, such as cIAP-1, cIAP-2, and XIAP, in rat islets.
Certainly, it would disappoint Thomas Jefferson, who once opined, "The benefit even of limited monopolies is too doubtful to be opposed to that of their general suppression".
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Nevertheless, since denosumab is a 'biologic' and the Rank-Ligand-Rank system is ubiquitous throughout the body, general immune suppression must be a safety consideration, especially in patients with immune suppression, including the other biologics and post-transplantation.
However, overall this represented less general antimicrobial suppression than observed for the strains known to secrete secondary metabolites (growth suppression of an average of 12 (range 10 14) and 12 (range 2 14) fungi and bacteria, respectively) (Fig. 3).
In general, the suppression of RY patterns is stronger in protein-coding regions, although several phyla exhibit significant RY pattern suppression in intergenic regions as well (Supplementary Tables S10 and S11).
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