Moreover, our findings introduce a novel antibody-based tool that, as a consequence of its general specificity for fibrillar conformations and its ability to function intracellularly, offers broad research potential for a variety of human amyloid diseases.
These factors were chosen because they represented qualitative descriptions of the general specificity or nonspecificity of chemicals with regard to the activity in rodents and have some bearing on the potential activity of chemicals in humans.
In this study, we evaluated the magnitude, general specificity and character of HIV specific CD8+ T cell responses at four time points across 2-9 years in 2 groups of chronically infected individuals separated on the basis of either effective antiretroviral suppression or ongoing replication of HIV.
Magnitude, general specificity and character of the HIV-specific CD8+ T cell response changed little over the study period.
In our study, where initial samples were drawn at least 3 months after establishment of viral suppression or viral replication, the absolute magnitude, general specificity and subset distribution of the CD8+ anti-HIV T cell response remained remarkably constant.
The fractional contribution of each individual HIV protein to overall magnitude indicated general specificity.
In general, the specificity of thermoreceptors is quite narrow, in that their nerve endings are excited only, or primarily, by thermal stimuli.
In general, the specificity of TopHat, MapSplice and HMMSplicer drops with the read coverage, where PASSions specificity remains high with specificities >97%.
The general taxon specificity of scaffolds was confirmed by the fact that less than 0.8% of all scaffolds were homologous to both the Tc and Dp genomes.
As a general observation, specificity of all tests was higher in cubs, although only significantly so in the case of the Brock Test.
