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In the general population trials included in the recent ATT meta-analysis of data from 95,000 subjects, there was no convincing evidence of an interaction between age or sex and aspirin effects on CVD or all-cause mortality (6, 16).
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Thus, the means and quantiles for the serum 25(OH D concentrations given for the subcohort in Table 2 are estimates of the means and quantiles of the entire General Population Trial cohort and not, as is generally the case, the means and quantiles of those who never develop the cancers under study.
Vitamin D was not included in the General Population Trial as an intervention agent.
Subjects were selected from the cohort of all participants in the General Population Trial of Linxian.
The General Population Trial enrolled individuals between 40 and 69 years old from the general population of four communes in the high-risk Linxian cancer area.
A large number of etiologic studies have also been conducted using data from the Nutrition Intervention Trials General Population Trial cohorts, which included over 29,000 participants.
Subjects were selected from the cohort of all participants in the Linxian General Population Trial, which is described elsewhere (Blot et al, 1993; Li et al, 1993).
The mean values and quantiles were calculated using the known sampling weights from the entire General Population Trial cohort for each individual in the study.
Individuals who died or developed cancer in this 1-year interval were excluded from the General Population Trial and this analysis.
We used a stratified case cohort design (Prentice, 1986; Self and Prentice, 1988) to select individuals for serum measurements from the cohort of all participants in the General Population Trial.
Vitamin D was then measured in all of the selected participants who had available serum (Dysplasia Trial: incident liver cancers: 29, chronic liver disease deaths: 29, controls: 131; General Population Trial: incident liver cancers: 197, chronic liver disease deaths: 253, controls: 932).
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