None the less, the archaeological record for southern Africa seems to indicate an increase in sites (and perhaps the general population size) during the last 4 ka.
In general, increasing population size would reduce experimental errors thus improving the power of detection.
Presumably, selection against boundary changes will be inversely related to the availability of true alternative boundaries, and the overall efficacy of selection in general (effective population size).
In general, when population size varies over time, it is not always true that most coalescence occurs during the early phase of a sweep, and we therefore do not adopt this assumption here.
In general, the effective population sizes of the descendant populations are well estimated, but the estimates of NA are reported to be sensitive to model misspecification (Becquet & Przeworski, [ 38]).
As the SF-12 has rarely been used in intervention studies among the general population, the sample size calculation was based on the SF-36 [ 12].
The incidence of myocardial infarction is twice that of the general population and infarct size, for a given ischemic insult, is larger [ 7, 8].
One CRC risk factor for people in the general population is body size, a collective term for body mass index (BMI), waist circumference and height (Dai et al, 2007; Larsson and Wolk, 2007; Moghaddam et al, 2007; Renehan et al, 2008).
The strengths of this study are the cohort design, the large population size, the general population base for the study cohort and the adjustment for important potential confounders, especially TB incidence in the country of birth.
