Sentence examples for general population frequency from inspiring English sources

Until a functional test is available, general population frequency analysis of unclassified variants in the BRCA1 coding region is useful to support the putative role of missense mutations.

Compared with the general population frequency in New York, the 1100delC variant appears to be even rarer among breast cancer patients from Spain [ 11] and India [ 12], where studies to date have reported no individuals with the 1100delC variant.

This is at a much-increased rate compared with the general population frequency (approximately 0.25%) 9 and, in the probands, is a significant increase over that observed in our comparison participant samples (p=0.012).

The analysis was implemented to have a low stringency for the initial variant calling, in order to minimise the false negatives, but it relies heavily on intersection filters for controls and general population frequency to rule out non-causative mutations.

It has been observed that, while the frequency of skin conditions such as acne, urticaria and atopic dermatitis are reduced in patients with psoriasis compared with expected frequencies in the general population, the frequency of some noncutaneous, although related, conditions is significantly increased [ 26, 53].

Intermediate alleles are relatively common in the general population with frequency estimates between 1 and 7%.

In the general population, the frequency of grey zone alleles is 3-4/100 males [ 16, 19].

In up to 40% of the general population low frequency sleep spindles persist after puberty [ 21, 32, 39, 40, 46].

Controls (n=676) were randomly selected from the general population and frequency matched to cases by age and sex.

In the general population, the frequency of Klinefelter syndrome in men or Triple X syndrome in women is about 0.1%.

Controls were selected from the general population and frequency matched to cases on sex, age (5-year intervals) and race.