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A general disadvantage of CO2, however, is that it is a very poor solvent for high molecular weight or hydrophilic molecules.
While dependence on data quality is a general disadvantage with data driven bottom-up approaches, model based top-down reconstructions are much more robust.
The binary scale was chosen for convenience, but it is certainly possible that lower reliability scores reflect the general disadvantage of checklists relative to general rating scales [15].
As a general disadvantage from these standard databases, in the mono-camera scenario specially, only a few suspects have been selected, this is because cameras are overlapping and there are not many different suspects to select.
A general disadvantage of the MRIO approach when applied to critical materials is that tracing critical materials through IO tables requires gross assumptions about homogenous product mixes, as the aggregation level of I/O is usually so high that it does not allow to distinguish specific critical metals from the bulk of nonferrous metals.
The problem may be that standardized tests in general disadvantage some students.
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In addition, the general disadvantages of time series analysis apply to our method (see for example Chatfield 2004).
General disadvantages relate to confounding, which refers to differences in the distribution of risk factors other than the exposure of interest between exposed and unexposed groups.
As postoperative administration of RT has some general disadvantages, neoadjuvant approaches could offer benefits in terms of dose escalation, target coverage and reduction of toxicity, especially if highly conformal techniques like intensity-modulated radiation therapy (IMRT) are considered.
General disadvantages of the case-control design principally relate to the problem of recall bias, where individuals with the disease of interest tend to overestimate relevant past exposures [ 92, 93].
can achieve significant suppression of the complex inflammatory network and ameliorate the disease, they are still subject to the general disadvantages associated with protein drugs, such as insufficient immune response to infectious agents and autoimmunity [ 1, 2].
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