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"There is the risk of a general destabilization of large areas," said Aleksandr K. Nikitin, a Russian environmentalist and an expert on nuclear safeguards.
The Ukrainian government, Ukrainian militants and Russian forces have been tangling in the area for months, with Russia annexing Crimea along the way, hundreds dying on the ground and general destabilization taking place.
These data contrast with the general destabilization behavior predicted to take place as a part of the yeast response against moderate oxidative stress [4].
In addition, the modelization of Gigaxonin structure allows us to map GAN mutations and predict a general destabilization of disease-associated mutants, which is further confirmed by reduced half-lives of mutant Gigaxonins.
If, however, the effect were more global, such as a general destabilization of the protein, then remediable alleles may occur at a considerable distance from the cofactor-binding site.
This may reflect the difference between a specific destabilization of the top of β-sheet A by the Z point mutation [ 6, 7, 17] and a more general destabilization of the β-sheet A under thermal stress.
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Thermal stability of the siRNAs 2 19 was also considered by thermal denaturation CD experiments highlighting a general thermodynamic destabilization for all modified duplexes.
It has been difficult to obtain more direct evidence of a role for PABPC1 in the miRNA pathway (i.e. using RNAi knockdowns) because depleting PABPC1 causes rapid cell death and general mRNA destabilization (Behm-Ansmant et al, 2007).
Subsidence produces a local and general kyphotisation and destabilization which increases bone stress at the screw-bone interface [14].
Forcing saturation on a previously designed controller may in general lead to destabilization or at least result in performance losses.
Over and over for bacterial cytoskeletal and cytoskeletal-like elements, we are seeing spontaneous nucleation followed by spatially localized stabilization or destabilization as the general organizing principle.
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CEO of Professional Science Editing for Scientists @ prosciediting.com