This is based on the rationale that comparing DF, DHF and DSS patients together should improve the probability to identify a DSS-specific gene signature, while including an external non dengue control group should increase the probability to identify a general dengue-related signature but should be less powerful at identifying a signature of severe dengue disease.
In general, maternal dengue antibodies may play a dual role in the pathogenesis of the dengue disease in the neonates.
This resulted in a number of useful general recommendations: dengue should be notifiable, regional disease classification applied, electronic reporting developed, laboratory networks initiated, reporting focussed at the essentials, additional studies done and early prediction of outbreaks achieved.
In general, the dengue IgG prevalence of young adults in Singapore (aged 16 25 years) is much lower (16.1%) in comparison to those of younger or similar age in other endemic countries.
Understanding the KAP of the general community on dengue and prevention will provide valuable information for effective strategic planning and engaging the public in dengue control.
In another interesting study, Kruif et al (2008) reported a general association of dengue severity and up regulation of genes involved on innate immune response during acute phase of infection in children [42].
This reflects the general pattern of dengue evolution in the Americas (13, 14 ).
The general knowledge of dengue was similar between teachers, parents, and principals who participated.
I think that this issue would contribute to the understanding of FcγRIII activation on mast cell in general and on dengue pathogenesis in particular, thus increasing the importance and novelty of the study.
According to Brigadier General George H. Toney, dengue caused a "small constant non-effective rate" among the troops (9 ).
