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It remains to be determined whether aPPD alters raft resident proteins by causing a general alteration in the fluidity of the membrane, similar to other cholesterol derivatives, or whether the compound directly interacts with specific proteins in the lipid rafts to modulate their activity.
The bat's initial change in direction is only a general alteration of its course, but, as it approaches the insect, the bat constantly modifies its course to obtain an accurate interception.
A general alteration of thymic histological structure occurred in the CORT group.
This "relates to a more general alteration in the events and tone of the film" rather than significantly changing the underlying themes.
The MDR phenotype is often linked to with a general alteration of membrane properties including a decrease in membrane permeability associated with an overexpression of efflux pumps [5].
The depletion of large vertebrate consumers relative to their prey has caused a skewing of trophic structure towards dominance at lower levels and the general alteration of food webs [36], [37].
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Immunosenescence is a term that is often used to describe the general alterations that occur within the immune system.
E. coli generates multiple barriers to protect itself from different classes of harmful, foreign compounds, and we found, as expected, that many of the loci responsible for general alterations in susceptibility encode enzymes that synthesize cell envelope components.
Interestingly, down-regulation of glycolytic enzymes (PYGM, Pgm2, GAPDH and PGAM2 - GO 0006006) and phosphagen regulatory enzymes (CK-M - GO 0016772) suggests that there is a strong glycemic imbalance and, in general, alterations in bioenergetic pathways in AQP4−/− muscle.
In general, alterations in integrin activation or expression promote tumor growth and metastasis.
However, this reduction was not a reflection of general alterations in breast tumor cell growth (Additional file 9).
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