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Exact(37)
The gene was linked to another piece of DNA, one that serves as an on-switch for the gene.
The short version of the gene was linked (if weakly) to neuroticism, as a personality trait -- the news media called 5-HTT the "Woody Allen gene".
Further the LHRH 6leu) gene was linked to heat-labile enterotoxin of E. coli (LTB) as carrier.
Briefly, a 5′-end breakpoint of a RNA fusion gene was linked to an SV in DNA if (1) the SV orientation supported the fusion product and (2) the DNA breakpoint was the same or downstream of the RNA breakpoint, up to the transcription end site.
Hui realized that the knocked-out gene was linked to another gene that might be compensating for it.
The UK study, published in the Annals of Rheumatic Diseases, looked at 4,600 people and found the PARK2 gene was linked to age-related disc problems.
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It is a long road, however, from knowing a variant gene is linked with a disease to understanding the biology of how the disease is caused.
A fascinating finding has been that the degree of damage within the MC4R gene is linked to the amount of calories that are consumed.
The targeted gene is linked with a gene that produces white fur, making it easy to see which mice have been successfully edited.
For instance, the APOE gene is linked to the breakdown of fat, and one variant of it confers a higher risk of getting cardiovascular disease and dementia.
Beadle himself catalysed the transition from classical to molecular genetics when, together with Edward Tatum, he discovered that each gene is linked to the production of a protein.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com