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In fact, the conditional knockout of the normal gene triggers neuronal degeneration in the postnatal brain.
In the mouse, deficiency of the Foxp3 gene triggers a rapid fatal multi organ autoimmune disease [ 2, 3].
The BoOr mutated gene triggers the biogenesis of chromoplasts, which serve as metabolic sinks for carotenoid accumulation [ 16, 17].
ATG1 is necessary and sufficient itself to induce the autophagic process in Drosophila: overexpression of this gene triggers downstream pathways and stimulates autophagy in a kinase-dependent manner [ 37].
A mutation of the CTG repeat in the 3′UTR of the DMPK gene triggers DM1 (25, 25), whereas an abnormal stretch of CCTG repeats in intron 1 of the ZNF9 gene causes DM2 (Fig. 1) (26).
For example, insertion of Tgm-Express1, a member of CACTA family of transposable elements, in intron 2 of the glycine max flavanone 3-hydroxylase (F3H) gene triggers alternative splicing of the mutant transcript.
Similar(53)
(In 1996, researchers found that soybeans modified with a Brazil-nut gene triggered allergies in test subjects; the product, which had been designed to have a higher amino-acid content, was never commercialized).
Depletion of p300 or SRC-3 resulted in a significant reduction in transcription of the endogenous EPO gene triggered by hypoxia.
The binding of a steroid molecule to its receptor causes the receptor to move into the nucleus and interact with a specific gene, triggering transcription of that gene.
2) Internal exon added to host gene triggered recruitment of an additional protein coding exon from formerly intronic sequence (dark blue).
We also observed the cell death development under Ni-U microscope and found that the VIGS lines with SlybHLH131 gene triggered a rapid cell death response in comparison with empty vector lines by trypan blue and DAB staining.
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