From Table 10 we see that there is a far greater amount of enrichment groups for Leukemia data, independently of the underlying gene selector: GSEA returned 45, 21, 12, and 7 statistically significantly enriched gene sets for iRDA, CMIM, mRMR, and FCBF.
We employ performance measures for assessing the gene discrimination of the gene selectors under consideration.
Here, we exploit a non-parametric classifier, kNN (for k = 3), for building inductive models from the results produced by gene selectors.
For example, iRDA has 6, 19, and 16 enrichment groups based on 7, 9, and 26 collapsed genes for the Brain, Lymphoma, and Prostate instances, respectively, while there are a fewer enrichment groups identified for the other three gene selectors based upon a larger number of collapsed genes (see Table 9).
We conducted an experiment about computation time with regard to the four gene selectors applied to all of the 11 gene expression profiling data in the environment of MATLAB 7.14, with the hardware being an Intel Core i7-3820 CPU of 3.60 GHz and a 24 GB RAM.
He continues by explaining how the biocoid protein differentially activates a set of six gap genes, which in turn differentially activate and deactive eight pair-rule genes, which differentially activate and deactivate segment polarity genes and homeotic selector genes.
Adjacent developmental compartments are distinguished by differences in the expression of particular genes, such as selector genes.
These analyses suggest that cells in the DT and DB domains may be regulated by genes with "selector" function (Garcia-Bellido, 1975), and establish the coincidence of lineage restriction and the expression domains at single cell resolution.
Selector genes regulate genes important for proper differentiation and genes that control cell−cell interactions at the compartment boundary.
Conforming the classical selector gene hypothesis, these genes determine the identity of a specific compartment; alteration in their function (gain or loss) causes the corresponding alteration in compartment identity.
Subsequent molecular studies have fully validated the selector gene hypothesis: the homeotic genes and en have expression patterns that correlate precisely with the cells that require their functions.
