Sentence examples for gene selectivity from inspiring English sources

To find out whether the DNA-binding of p53 phosphorylated at S46 plays a role in target gene selectivity, in particular for the selection of apoptotic target genes, we studied genome-wide DNA-binding profiles of p53 phosphorylated at S46, and analyzed the binding profiles of p53 phosphorylated at S15 in comparison.

The results indicate that both HIF- α isoforms bind in vivo to the HREs of target genes predominantly activated by one isoform alone, suggesting that HIF- α target gene selectivity in VHL-defective RCC and other cell types is not due to selective DNA binding.

Mutant ARs exploit multiple mechanisms to resist hormone ablation, including alterations in ligand specificity, target gene selectivity, chaperone interaction and nuclear localization.

Besides post-translational modifications, chromatin remodeling is also involved in the target gene selectivity of p53 target genes.

Thus, in the future the role of additional miRNAs on p53 target gene selectivity has to be elucidated.

Future research should elucidate how p53 PTMs influence the interaction with co-factors and what result this has on p53 target gene selectivity.

Here, we add a new mechanism by which Che-1 controls p53-mediated response: Che-1 and p53 interact and this interaction is involved in the regulation of p53 target genes selectivity, directing p53 transcription towards growth arrest genes.

To further ensure high primer selectivity, touch-down gene selection PCR was conducted starting with a high (70°C) annealing temperature.

Such differences indicate the high tissue- and gene-selectivity of genomic hydroxymethylation even within genes that encode proteins in the same signaling pathway.

This therapeutic strategy will achieve two levels of targeting for t(4; 14) MM: tumor cell selective delivery by the SLAMF7 antibody and gene pathway selectivity by the MMSET siRNA.

An important determinant of gene promoter selectivity of activated ERs in vertebrates is their ability to bind to sequences of DNA called estrogen response elements (EREs) within the promoter of target genes (Hall et al., 2001).