Exact(2)
However, a significant amount of experimental data from individual gene proposes that tumor cells have a metastatic signature [ 31, 32].
The dominant-negative hypothesis for WT p53 inactivation in cells carrying a mutation in one of the alleles of the TP53 gene proposes that the presence of even a single mutant protein in the formation of the p53 tetramer would lead to loss-of-function of p53 [ 87, 88].
Similar(58)
Another gene proposed to be a member of the group called RAD61[ 19] was also not required for repair of the EcoRI-induced DSBs.
The lineage-specific arrangement of SWEET genes proposes that the genes may be expanded and then diversified after the monocot and dicot division.
However, although some gene-hunting efforts have been conducted and a few risk genes proposed, IBS genetic research is lagging behind compared to other complex diseases.
Among several radionuclide reporter genes proposed to date, the human sodium/iodide symporter (NIS) reporter gene appears to be the most promising [11].
The mechanisms of visceral pain and RAP are not fully understood, a heritable component has been demonstrated, and a few candidate genes proposed.
Nevertheless, differential susceptibility may be more adequately accounted for by multiple genes, proposed to have cumulative effects [38], [55].
Candidate chromosome 1p brain tumor suppressor genes proposed so far, TP73 [13], RAD54 [6], CDKN2C/p18INK4c [14] and CHD5 [15], are located on distal 1p.
For each pathogen considered, 7 to 40% of the 10 15 best candidate genes proposed by PHYLORPH yielded sequencing success.
Similar results were obtained in the study of gene expression stability in tomato [24] – one of the few studies adopting new reference genes proposed in [9].
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