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He and colleagues have now found that caloric restriction appears to work through the SIR2 gene pathway.
In addition, we were able to identify common gene pathway profiles associated with the presence of these mutations.
Due to the extreme rarity of some individual variants, gene-based association tests have been proposed to aggregate the genetic variants within a gene, pathway, or specific genomic region as opposed to a one-at-a-time single variant analysis.
Roeland Nusse, Professor of Developmental Biology at Stanford University and Investigator at Howard Hughes Medical Institute, for his work exploring the Wnt gene pathway and its implications in cancer.
The state model adopted here is motivated by gene pathway diagrams commonly encountered in biomedical research, in which genes act to activate or inhibit the activity of other genes.
In the study, researchers highlighted a gene pathway called p53, which regulates "programmed cell death", a kind of cell suicide.
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Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance.
Using these expression profiles, we identified a 73-gene pathway as the most significantly up-regulated pathway in PD (MORAN-PD-UP, Figure 5).
Our trained model was applied to all gene-pathway pairs tested in these RNAi screens.
In Chem2Bio2RDF, there are eight kinds of relations: compound-compound, compound-gene, compound-disease, compound-side effect, compound-pathway, gene-gene, gene-disease, and gene-pathway.
Candidate genes were extracted for the 12 pathways via gene-pathway mapping on KEGG (the Kyoto Encyclopedia of Genes and Genomes) database [29], [30].
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