Sentence examples for gene modifications from inspiring English sources

This was markedly different from the one-by-one gene modifications of recombinant DNA research, since numerous genes were linked together to create a new genome.

The problem may be extra copies of a crucial gene, damage to a gene, modifications that affect a gene's function, or the merger of two chromosomes to create a novel gene not seen in healthy cells.

This is because the gene modifications are crafted based on knowledge of what genes do, in contrast to the shotgun approach of traditional breeding or using chemicals or radiation to induce mutations.

Transgenesis includes two complementary gene modifications: foreign gene addition to animal genomes and gene replacement.

Significant effort was dedicated to identifying the molecular regulators of these processes and the developmental defects resulting from gene modifications.

To consider the potential influence of off-target gene modifications (Yee, 2016), we detected the most probable ten off-target modification sites which were designed at the CRISPR website (http://crispr.mit.edu/) (Supplemental Table. 3) and found that there was no off-target gene modification (Supplemental Fig. 2), which excluded the potential influence of off-target gene modifications.

Further, to consider the potential influence of off-target gene modifications (Yee, 2016), we detected the most probable ten off-target modification sites which were designed at the CRISPR website (http://crispr.mit.edu/) (Table S3) and found that there was no off-target gene modification (Fig. S2), which excluded the potential influence of off-target gene modifications.

However, in this technique, gene modifications of metabolic control architecture as well as enzyme expression levels are coupled and result in a mixed integer nonlinear programming problem.

The subsequent activation of the DNA repair machinery then enables the introduction of gene modifications at the target site, such as gene disruption, correction or insertion.

By contrast, longevity, robust proliferative potential and the capacity to reconstitute the wide-ranging diversity of the T cell compartment are more critical for cells with permanent gene modifications.

All in all, these data indicated that the phenotypes in these Clock knockout mESCs should mainly be due to the loss of Clock but not the influence of off-target gene modifications or loss of other Clock functions.