The general findings, though with other SNPs in this gene, were replicated in series of other European populations [7].
More importantly, the association with the SOX6 gene was replicated in an FHS cohort, a family-based study sample that is typically free from interference of population structure.
Interestingly, haplotype A-tagging SNP e26 in the DLG5 gene was replicated (over-transmission of common allele T, T∶U = 275∶219, p = 0.012), while the associations of non-synonymous SNPs Arg30Gln and Pro1371Gln did not reach statistical significance.
A single array contained 2698 different genes, each gene being replicated at least 4 times on each array.
Among the 16 genes that showed a positive association in at least one study, four genes were replicated in at least a second article, three genes were replicated in at least three studies, and one gene was replicated in four studies.
The association of one common single nucleotide polymorphism (SNP) located upstream of the CDH13 gene was replicated with HYP and DBP in two independent study populations from Germany and Estonia.
Each combination of strain and targeted gene was replicated in at least eight wells, and within each well an average of 10 adult worms contributed hundreds of offspring that were screened as dead or alive.
Replication analyses of the three significant TBL markers identified in Study 1 were performed using data from Study 2. Only the TA-repeat polymorphism from the UGT1A1 gene was replicated (P<0.01).
Heterochromatin, in contrast, appears condensed with relative even spacing of nucleosomes, is thought to have a more "closed" conformation, comprises few genes, is replicating late in S-phase, and is largely transcriptionally silent (for review see [1].
