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Sequence analysis revealed a mutation in the DMD gene in the case of the DMD patient, whereas for the EDMD/CMT the underlying mutation could not be identified.
The expression of H19 gene in the case of Balb/3T3 was significantly reduced after treatment with 5 mM and 10 mM concentrations when compared to control.
This form of parallel evolution is best explained by selection for increased gene dosage in the case of duplications [ 16, 22, 25, 27], and selection against a gene in the case of the deletions [ 45– 45].
Functionally active ABC transporters contain a minimum of two highly conserved hydrophilic cytosolic nucleotide-binding domains (NBDs) and two hydrophobic transmembrane domains (TMDs), which are encoded by the same gene in the case of 'full transporters'.
TRANSLATIONAL IMPACT Clinical issue Huntington disease (HD) is one of several genetic neurodegenerative diseases that are caused by the expansion of trinucleotide CAG repeats in certain causative genes (the huntingtin gene in the case of HD).
In the M9 adaptation, however, deletions (Δ1, Δ2, and possibly Δ4) in the early region occurred that were limited to design elements (and perhaps remnants of a deleted gene, in the case of Δ4), suggesting those elements were specifically detrimental.
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By examining neighbouring genes, we also found evidence for potential cotransfer of additional genes in the case of the ARG pac (conferring resistance to puromycin).
Three genes in the case of HSV and CMV and two genes in the case of VZV per organism were amplified for identification, while single genes were targeted for Toxoplasma and MTb.
Although the difference between the TopK-Gene and CAVIAR-Gene in the case of one causal gene is negligible, we observe a 10% higher recall rate when there are multiple causal genes in a region (Fig. 2b, d, and f).
(These numbers differ due to the criteria for eliminating genes in the case of missing values).
Hence, selection might have occurred against deletion or deleterious mutations in MHC I genes in the case of CTVT.
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