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Gene List X (2,344 gene features) represents the genes that were differentially expressed between clusters A and B, whereas gene List Y (1489 gene features) represents the genes that were differentially expressed between clusters B and C (Figure 2A).
First, SNPs are given preliminary risk scores according to their gene features since SNPs of different gene features may have different disease risk [7].
Of particular interest were 106 gene features that were affected by rapamycin in both cell lines.
Only the gene features with signal background ratio more than 1.5 were used for analysis.
The most evident property is their gene features, if available [7].
A cross comparison of expression patterns (Figure 1A) showed that 791 gene features were exclusively altered in WB-F344 cells after rapamycin treatment while 484 gene features were exclusively altered in the WB311 cells.
Gene features such as lipoprotein attachment site and signal peptide sequence were identified using the Biology workbench 3.2 (http://workbench.sdsc.edu).sdsc.edu
The Affymetrix gene features affected by rapamycin in the WB-F344 and WB311 cells were subjected to further analysis.
A majority of these gene features overlapped among multiple classifiers.
The other gene features separate in the proceeding components.
The gene features an ORF of 1959 bp without introns.
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