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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
Tissenbaum, H. A. & Guarente, L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
This gene extends over 42.8 kb and encompasses 41 exons (http://genome.ucsc.edu/).ucsc.edu/
Accordingly, the distribution p(F; gene) extends to lower values in fitness, when a network evolved under small phenotypic noise is developed under a higher noise level.
The NPSR1 gene extends for 220 kb of genomic DNA on chromosome 7p14, and more than 1400 SNPs mapping within this region have been identified through sequencing of individuals of different ethnicity.
There are reports that overexpression of the adh1 + gene extends lifespan in S. cerevisiae [ 35] and in S. pombe [ 36].
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But why would slightly disabling the gene extend the life span?
Up to now, the RF gene extended families are deposited into the databases with arbitrary naming system by authors.
In fact, the overexpression of Sir-2 [15] increased lifespan up to 50% in C. elegans but in Drosophila, an extra copy of the Sir2 gene extended lifespan in female and male by 29 and 18%, respectively.
The Thy-1.2 vector contained 6.5 kb of the murine Thy-1.2 gene extending from the promoter to the intron following exon 4, without exon 3 and the flanking introns [21].
Here we show that the human BDNF gene, extending over 70 kb, contains 11 exons.
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