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Membrane-bound low molecular weight GTPases of the Rho (Rho=Ras homologous) family play pivotal roles in the regulation of a variety of cellular functions, including proliferation, gene expression, transformation and apoptosis as well as actin cytoskeleton-related functions such as cell motility and cell adhesion.
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In both cases, co-transformation of wt bZIP63 and AKIN10 strongly induced reporter gene expression, while transformation of bZIP63 alone was not sufficient for significant induction.
Hence, we have focused our attention to the work done on stable gene expression and transformation of wheat by employing microprojectile bombardment and Agrobacterium as a source of foreign DNA delivery into immature embryos.
This warrants further investigation, including gene expression and/or transformation of closely related teleomorph species.
PTTG-1-IP is a protein that binds PTTG, a protein with multiple regulative functions in mitosis, gene expression, cell transformation and also angiogenesis [ 72].
To quantify gene expression the transformation control plasmid p70Sruc harboring the luciferase gene from Renilla reniformis under the control of the doupled CaMV 35S promoter was employed as a second reporter gene [ 38].
The ability to identify structural changes in cells and tissue, especially at the nanometer scale during disease processes (e.g., cell differentiation, proliferation, gene expression, malignant transformation) has important implications in biomedical research and clinical diagnosis.
These studies suggest a tumor suppressor role for PRC2 in human leukemia and suggest a hitherto unrecognized dynamic interplay between oncogenic NOTCH1 and PRC2 function for the regulation of gene expression and cell transformation.
To characterize the quantitative and qualitative differences in gene expression during tumor transformation, the chapter describes the conditional reconstitution of the expression of an activated K-ras allele in the K-RasD13 knockout cell clones DKO-4 and Hke-3.The Hke-3.Theresents a set of experiments designed to identify transchapterthat respresentsK-Rasetctivity.
Genetic as well as epigenetic dysregulation of gene expression during malignant transformation is attributable in part to aberrant expression of micro-RNAs (miRNAs) [1], [2].
Temperature shifts trigger differential gene expression and stage transformation in Leishmania[ 32].
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