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Also, for certain essential genes we suspect that there may be a low degree of gene expression requirement for bacterial viability.
Many putative essential genes have been identified or predicted in several species, however, little is known about gene expression requirement stringency, which may be an important aspect of bacterial physiology and likely a determining factor in drug target development.
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Thus, trypanosomatids must use post-transcriptional control mechanisms to balance gene expression requirements.
These genes met the FDR <0.05 and ≥2-fold difference in gene expression requirements, and included genes encoding glycoside hydrolase and CenC carbohydrate-binding proteins (Cthe_1256 and Cthe_1257) (Table 4).
The differentially regulated miRNAs were unique with almost no overlap between the two time-points, indicating that miRNA expression changed transiently according to the temporal gene expression requirements in the lungs.
The identification of this module by DetMod can be interpreted byway; it incorporates members that entered the module after complying with the gene expression requirements but also its members have strong functional correlation on the PPI network.
To conclude, our findings regarding Zfp335R1092W add to other recent work (Hsu et al., 2011; Landry et al., 2011; Silva et al., 2014) to highlight unique gene expression requirements in late stage thymocytes and recent thymic emigrants for the formation of a normal sized naïve T cell compartment.
Multivariable linear regression analysis of gene expression using requirement for blood transfusion, diagnosis of cancer, duration of the surgical procedure, age, ASA class and the presence of preoperative immunosuppression transfusion as potential independent variables.
This new figure arrangement strongly supports our conclusion that the crosstalk-amplification of LPS induced NF-κB target gene-expressions requires p52 Nfkbutbut circumvents the requirement for RelB NF-κB transcription factor.
Since accurate gene expression is an essential requirement for all living cells, several surveillance mechanisms have evolved at the RNA level in both the nucleus and the cytoplasm [reviewed in 14] [16].
Chromatin modifications are known to impose epigenetic controls on gene expression without any requirement for changes in DNA sequence.
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