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Thus, for RYR1 there is not yet a clear causal link between an aberrant genotype, epitype, and the silenced RYR1 gene expression producing the disease (Table 1).
56 In addition, the use of adenoviruses has allowed to restore Ift88 gene expression, producing functional olfactory cilia which were absent due to a mutation responsible for the development of Oak Ridge Polycystic Kidney disease, what could be applied to other human ciliopathies.
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Figure 2A shows the changes in gene expression produced by each nutrient, expressed as fold change (log2) relative to quiescent samples.
Unsupervised hierarchical clustering of gene expression produced two major groupings: diagnostic leukemia cells and normal leukocytes formed two discrete clusters (Figure S1), with 58% of the genes exhibiting discordance in gene expression (p<0.001) between the two primary tissue types.
Estimation of true and false selections are based on the proposition that after arbitrarily chosen split the resulting subgroups have only changes in gene expression produced mainly by the controlled modifications in one of the subgroups.
To gain insights on the global changes in gene expression produced by the exposure to the Aβ-Al complex in human SH-SY5Y neuroblastoma cells, microarray analysis was performed and results selectively compared with gene expression of cultures exposed to Aβ or Al.
To determine the alterations in global gene expression produced by suppression of UCH L1 levels, we used HEK 293T, SV40-transformed human embryonic kidney cells that grow as an adherent culture, and KR4, an EBV-transformed B-cell line that grows in suspension.
These findings show that variation in 5-HTT gene expression produces robust changes in anxiety and species-typical behaviour.
We use gene expression data from the FANTOM5 project [ 8], which represents the largest atlas of cell-type-specific gene expression produced to date.
3. Small elevations in inflammatory gene expression produced during upper respiratory infections generally return to normal levels of expression within two weeks after the infection has resolved.
Changes in gene expression produced by cAMP alone are plotted on the Y-axes, and the responses to the nutrient with cAMP on the X-axes.
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