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Altogether, this method will likely be particularly useful for genes with multiple separate functions, genes expressed in many tissues, as well as in cases where altered gene expression causes embryonic lethality.
However, the exact mechanism of how the aberrant gene expression causes anti-tumor activity remains unknown.
FLO1 gene expression causes flocculation which is the Ca2 +-dependent, nonsexual aggregation of yeast cells [36 38].
Overall, direct demonstrations of how gene expression causes reproductive isolation remains a major missing link in connecting the role of gene expression to ecological speciation.
Roedder et al. have been reported in a renal transplant model that lower IFN- γ gene expression causes less infiltration of leukocytes and allograft rejection, demonstrating that this cytokine is associated with inflammation process and kidney injury [ 10].
Mitochondrial fusion is also dependent upon OPA1 expression (Fig. 2), where inhibition of gene expression causes an increase in mitochondrial fragmentation, conversely the overexpression of OPA1 breaks the network into spheres.
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These sequences, however, may cause undesirable effects such as the production of antibodies against bacterial proteins expressed from cryptic upstream eukaryotic expression signals, changes in eukaryotic gene expression caused by antibiotic resistance markers, and immune responses to CpG sequences [22].
Parental defects in the regulation of gene expression cause genomic imprinting defects that result in abnormal expression of maternal and paternal alleles and disruption of embryonic development.
In this study, we studied the immunotoxic mechanism and change of gene expression caused by the instillation of C60s.
The molecular pathways triggered in these cells induce marked changes in gene expression causing modulation of their cellular phenotypes resulting in proliferation, differentiation or migration.
Cocaine-induced alterations in gene expression cause changes in neuronal morphology and behavior that may underlie cocaine addiction.
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