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The analysis reveals how the cross-regulatory network is able to establish sharp gene expression boundaries (among target genes that, if expressed in isolation, would have a graded or uniform expression profile).
Nereis and Platynereis lack posterior Hox gene expression boundaries, consistent an absence of morphological boundaries.
Furthermore, Nereis and Platynereis lack spatial colinearity of anterior expression boundaries, and only two larval segments have corresponding Hox gene expression boundaries (Figure 15, [11]).
As a result to losing RA, rhombomeric and gene expression boundaries posterior to rhombomere (r) 3 are lost [46], [47], [52], [53], [54], [55], [56].
In contrast, a common theme across annelids is the apparent correlation between the presence of distinct body tagma and the presence of posterior Hox gene expression boundaries.
Examples of this behavior include sharp gene expression boundaries and the generation of traveling waves of mRNA expression from single 'trigger' patterns.
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The anterior-most Hox gene expression boundary is that of CapI-pb, whose anterior boundary is immediately posterior to the mouth.
In this system, the behavior near half maximal expression is biologically most relevant, since it is at this very concentration that the system has to 'decide' where to draw a fairly sharp gene expression boundary as one of the first steps in constructing a spatial pattern.
In this contribution, we illustrated how even a model using only a semi-quantitative description of the gene regulatory network acting on a tissue scale can help to guide the discovery of novel regulation mechanisms, in our case gene expression boundary sharpening induced by post-transcriptional feedback mechanisms.
Observed shifts in gene expression domain boundaries suggest that elongation in the planula stage mainly occurs in the vegetal ring under the influence of the gene Rx.
Despite the discontinuity arising from the sharp gene expression domain boundaries, we proved the existence of unique, positive solutions for the partial differential equation system.
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