Sentence examples for gene diversification from inspiring English sources

Gene duplications have occurred during plant speciation, and the generation of several paralogous copies allows gene diversification.

It was thus proposed that AID-triggered deamination of dC to dU and subsequent removal of U by UNG was involved in the first phase of hypermutation driving immunoglobulin gene diversification (Petersen-Mahrt et al., 2002).

The proposed function of AID and UNG in immunoglobulin gene diversification (Petersen-Mahrt et al., 2002) makes studies on possible B-cell abnormalities particularly relevant in an Ung-deficient mouse model.

FPs have been modified by a combination of rational design, structure-based mutagenesis, and countless cycles of directed evolution (gene diversification followed by selection of clones with desired properties) that have collectively pushed the properties to photophysical and biochemical extremes.

Monoubiquitination pathways may be important for regulating Ig gene diversification.

Deamination within the immunoglobulin loci by AICD initiates antibody gene diversification.

ELISAs for secreted IgG confirmed activation of Ig gene diversification (data not shown).

AID is predominantly cytoplasmic and must enter the nuclear compartment to initiate these distinct antibody gene diversification reactions.

These combined data demonstrate that CIB1 is not required for AID to mediate antibody gene diversification processes.

DT40 B cells disrupted for PCNA monoubiquitination by a K164R substitution showed decreased AID-initiated Ig gene diversification [14].

Control experiments showed that the PolyLacO tag does not affect cell proliferation, cell cycle profile or Ig gene diversification.