Since randomly ordered data should destroy correlations, we expect I to be close to zero, therefore, we calculated the minimum I for 100 random permutations of gene deviation vectors { V ti)}.
When using a single gene family to estimate divergence between species, as with the IRI-like genes, deviation from the average genome clock rate would be expected.
Analysis of internal gene model deviations suggest 42% of the expressed and selected set of L. bicolor gene models contain sequence deviations that largely represent intron/exon boundaries that do not map to the mRNA sequence data (Figure 3).
In addition to these main effects (genes as a group or tissues as a group), significant variation could be attributed to the gene-tissue interaction effect (F1680,5669 = 38.55, p<0.0001), reflecting gene specific deviations in expression across various tissues.
Most of the pioneering research has been done in Arabidopsis but at the same time many genes have also been identified and characterized in rice revealing gene function deviations or novel gene functions (for reviews, see [ 5, 6]).
High abundances of particular REP classes appeared to depend on the presence of the cognate RAYT gene, and deviations from this state could be attributed to recent or ancient mutations of rayt-flanking REPs, or RAYT loss.
However, as previously reported [3], rs6855911 in SLC2A9 gene showed deviation from HWE in gout cases (p = 0.01).
It is noteworthy that both SNPs located in SLC2A9 gene showed deviation from HWE in gout cases, which can in some degree support a true association [19], [20].
This latter result represents an important platform for future studies on Hox genes showing deviations from the archetypal topology.
Concerning CAT gene, the deviation from Hardy Weinberg Equilibrium in favor of homozygosis was not observed in these studies.
