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EhPTPA gene codifies for a 43 kDa native protein.
Cdkn1c gene codifies for the p57 protein belonging to the family of KIP/CIP factors that are cyclin-dependent kinase inhibitors (CDKI) involved in cell cycle arrest.
The RPS4 gene codifies for ribosomal protein S4, a very well-conserved protein present in all kingdoms.
Although this gene codifies for an enzyme which catalyses the formation of SFA, there was a positive association between ACACA expression levels and TFA.
This gene codifies for the 30S ribosomal protein S11 and has a strong SD sequence (the drop of ΔG° value is -11.44 Kcal/mol) at 10 nucleotides upstream to the start codon.
The Neverland gene codifies for an oxygenase-like protein that plays a role in the transport and/or metabolism of cholesterol, and hence it is located upstream in the ecdysone pathway (Gilbert and Rewitz 2009; Rewitz and Gilbert 2008).
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We found two of these sequences in the gene codifying for p63, laying in Ch3: 189,566,861-189,897,279.
Among the genetic determinants affecting the endophyte lifestyle, a gene codifying for β-galactosidase and two genes for the expression of acyl homoserine-lactones (AHL) were recently found in the genome of Methylobacterium sp. strain GFX4 [ 58].
The potential activity of nitrogen fixation has been phenotypically tested by the strain capability to grow in nitrogen-free medium and confirmed by molecular investigation by PCR amplification of the nifH gene, codifying for a subunit of the nitrogenase enzyme.
Among the up-regulated genes involved in our analysis, we then focused our attention on genes involved in protein ubiquitination (FBXO6, DTX3L) and in the assembly of immunoproteasome (PSMB8 gene codifying for LMP7 subunit).
Cdkn1a is the gene codifying for p21, which is a p53-dependent key regulator of cell fate, as it triggers cell cycle arrest in the G1 phase under various stress conditions [ 50].
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