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The mechanisms that regulate the probability of OR gene choice remain unclear.
More attention must be paid to odorant receptor gene choice and expression during development and neuronal differentiation.
Thus, the P and H elements regulate the probability of OR gene choice, not OR transcript level per OSN.
In an inbred mouse strain with a targeted deletion in the P element, we find that this element regulates OR gene choice differentially across its cluster of 24 OR genes.
The differential results in the various phylogenetic analysis can be attributed to misidentification of accessions, gene choice, use of insufficient data, introgression and hybridization, rapid speciation as well as lineage sorting (Wang et al. 1992; Zhu and Ge 2005; Zou et al. 2008).
In the last few years our understanding of these non-deterministic mechanisms is advancing, and this review will provide a brief summary of the current view of stochastic gene expression with focus on olfactory receptor (OR) gene choice, the epigenetic underpinnings of which recently began to emerge.
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Many methods have been used for selecting differentially expressed genes and the choice of the "best" gene selection methods has been under extensive debate [15], [16].
That will provide the basis for a researcher to study any mouse gene of choice through its absence in the mutated strain.
(D) Checked the transfer vector if it contained the gene of choice.
Databases, such as BRENDA [5], have experimentally determined values for many enzymatic characteristics that could be used in determining the gene of choice for each reaction step.
At almost every locus, a gamete has equal chance of receiving its grandmother's or its grandfather's gene, the choice normally being governed by the fairest lottery in all nature.
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