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In contrast to the conventional polycations with long sequences of covalently bonded repeating units, this work reports a supramolecular gene carrier where many cationic cyclic units are threaded over a polymer chain to form a chain-interlock structured gene carrier.
In vivo time-dependent gene expression of cationic lipid-based emulsion as a stable and biocompatible non-viral gene carrier.
Wang, Y. et al. Study on performance of magnetic fluorescent nanoparticles as gene carrier and location in pig kidney cells.
Ma, K. et al. Pamam-triamcinolone acetonide conjugate as a nucleus-targeting gene carrier for enhanced transfer activity.
The type of virus used as a gene carrier has widely been considered safe and is being used in 35 other trials.
However, gene carrier based on single materials suffers from intrinsic deficiencies.
Essential to effective gene delivery is the choice of gene carrier.
This novel cationic lipid was intended to act as a gene carrier with intrinsic antitumor activity.
FC-g-PEI copolymer was investigated as a potential cancer cell-targeting gene carrier.
Cell culture experiments indicated this BSA-based gene carrier possessed good cellular compatibility.
(10 μM RU486 treated no target gene carrier control, 5, 10, 20 μM RU486 treated Fgf3-GFP transactivation treatments) Corresponds to Fig1e.
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