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Myc gene amplification occurs in approximately 15 20% of breast cancer patients [36] and has been reported to be an independent predictor of survival in patients treated with tamoxifen [37].
Gene amplification occurs when multiple identical copies of a DNA sequence are duplicated within the genome.
AR gene amplification occurs in perhaps 30% of recurring HR tumors [ 22].
We conclude that MDM2 gene amplification occurs at a lower frequency in breast cancer than in non-epithelial tumours.
AIB1 gene amplification occurs in only a small fraction of ER positive primary breast tumors and breast cancer cell lines.
ERBB2 gene amplification occurs in 20 30% of breast cancer and is a strong predictor of poor disease prognosis.
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TERT gene amplification occurred in 57% of NSCLCs, but was more common among ADCs (75%).
Amplification of proto-oncogenes and possibly gene overexpression during the absence of gene amplification occur in the development of many human tumors.
The h TERT gene amplification occurred in 57% of NSCLC, but this was more common among ADC (75%) than SQCC (35%).
Yet, a recent report by Holst et al. [ 4] in Nature Genetics was the first to investigate whether a common mechanism of oncogene activation, gene amplification, occurred at the ERα gene locus during tumor progression.
This result, together with the fact that EBV and HER2 correlate differently with other tumour features, suggests that the viral infection and the gene amplification occur at different times during BC progression.
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