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In addition to the predominant mutations in the EGFR gene, alternative genetic changes between exons 18 and 21 have been observed.
Therefore, changes in expression of the tau gene, alternative splicing of its mRNA and its posttranslational modification can modulate the normal architecture and functions of neurons as well as in a situation of tauopathies, such as Alzheimer's disease.
hERG (human ether-à-go-go-related gene, alternative nomenclature KCNH2) is responsible for channels mediating the 'rapid' delayed rectifier K+ current (IKr) which plays an important role in ventricular repolarization.
Baseline level of plasma or plasma/muscle miR-499 ratio further predicts muscle response to RT, while changes in muscle miR-133a, -133b, and -206 may correlate with muscle TNNT1 gene alternative splicing in response to RT.
In addition, R gene alternative splicing was dynamic during the defense response (Gassmann 2008).
Alternative transcription initiation and splicing of mRNAs can produce multiple transcripts from a single gene; alternative translation initiation sites can then produce different proteins from each of these transcripts, and these protein variants can be targeted to different compartments in the cell.
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Gene expression data suggesting the preference of duplicate genes, alternative reactions, or alternative pathways can be utilized to constrain the simulations and improve computational modeling analysis.
Brosch, M. et al. Shotgun proteomics aids discovery of novel protein-coding genes, alternative splicing, and "resurrected" pseudogenes in the mouse genome.
The metabolic model contains redundancy in the form of duplicate genes, alternative reactions, or alternative pathways.
Without additional constraints, the duplicate genes, alternative reactions, or alternative pathways can all direct metabolic fluxes in simulations.
In mice, alternative splicing was detected in 47% of genes, alternative start site and alternative transcription termination was detected in 18% and 14% genes, respectively [ 54].
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