Sentence examples for gene alternations from inspiring English sources

Moreover, we discuss how F-box proteins involve in tumorigenesis via targeting cell cycle-related proteins using biochemistry studies, engineered mouse models, and pathological gene alternations.

Other issues that must be solved regarding nanoparticles include toxicity, gene alternations, penetration of the blood-brain barrier, and colloidal stability [ 1, 2, 5].

The 5-year DFS rates were 28.5 and 18.3 % for patients without and with BRAF mutation, respectively (median DFS, 11.8 vs 5.6 months; p = .03), and 31.3, 18.3, and 19.4 % for patients without any mutation and with gene alternations in BRAF and NRAS, respectively (median, 31.5 vs 5.6 vs 8.3 months; p = .04) (Fig.  2).

Cigarette smoking is the most important cause of lung cancer, and a number of smoking-related gene alternations have been identified that are responsible for the development of lung cancer, such as mutations in K-ras (Vineis and Caporaso, 1995; Shields, 2002).

pombe (WEE1) and caused gene alternation required for cancer development and progression [ 8].

Although the DNA microarray was employed to study the transcriptional gene alternation in cell lines and peripheral blood cells exposed to cadmium and identified several differentially expressed genes as well as signaling pathways [ 10, 11], the comprehensive understanding of the mechanisms that are responsible for the toxicity of chronic cadmium exposure in testis is still lacking.

Given their function in fine tuning gene expression, alternations in microRNA landscape could reflecting the underlying mechanisms of disease and present potential therapeutic targets.

By analyzing the gene expression alternations in the brains of male fetus and pups, data obtained revealed that the expression levels of genes related with oxidative stress, neurotransmitters, and psychiatric diseases were dysregulated.

According to the results of real-time PCR, it was shown that de novo DNA methyltransferases were involved in gene epigenetic alternations of OSCC.

To be surprised, we find that at very early age liver already exhibits serious gene expression alternations involving in bile metabolism dysfunction, inflammation, increased apoptosis and decreased proliferation, which greatly contribute to diabetes development.

Cell energy metabolism regulates KATP genes expression; alternations in the metabolism will lead to changes of the KATP channel number[ 12].