Sentence examples for gene altering from inspiring English sources

Another mechanism underlying imatinib resistance is point mutations in the BCR-ABL gene altering the conformation of the ATP-binding pocket such that imatinib no longer has affinity.

The disease state is caused by the reduced expression of a nuclear encoded gene, frataxin mediated by the repeat expansion of GAA within the first intron of the gene altering the epigenetic control of the gene transcription (6, 7, 38).

Although intelectin in the airway may serve as a novel defensive gene altering the response of asthmatics to infection, the contribution of intelectin to asthma pathogenesis requires further exploration.

The first arthritis regulating QTL to be cloned and positioned to one polymorphism is the Pia4, which was identified to be regulating chronic inflammation by a non-synonymous SNV in the Ncf1 gene, altering the amino acid at position 153 [ 52].

A causative variant may be a SNP located in an exon of a protein-coding gene (changing the amino acid sequence of the protein), a regulatory part of a gene (altering the expression level), or a copy-number variant of a gene [ 40, 41].

Whether silencing of the Clock gene altered the development of circadian oscillation of mESCs during differentiation remains unknown.

In fact, the only gene altered more frequently in this malignancy is VHL, a well-characterized driver of these cancers.

Disruption of the rgfC gene altered the bacterial binding to fibrinogen.

It should be noted that this was the only gene altered by castration in both the prostate and tumor.

The deletion of SO1377 gene altered iron metabolism.

Not a single gene altered in both in vitro systems was also altered in vivo.