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Annexin II, for example, stimulates cell proliferation and angiogenesis and is a putative receptor for tissue-type plasminogen activator (Tpa/Plat), another gene activated in Dbl-lenses, which generates plasmin, known to promote angiogenesis [34].
Collagen has broad utility as gene activated matrices, capable of delivering large quantities of DNA in a direct, localized manner.
Two weeks after having their backs shaved, mice who had their extra TERT gene activated showed significant hair growth.
To achieve this, we took advantage of Pou4f2 (Brn3b), a gene activated immediately as RGCs begin to differentiate and expressed throughout life.
Results showed an increased amount of non-adherent cells, especially erythrocytes, and von Willebrandt factor (vWF) and a yellow red appearance of gene activated scaffolds in relation to controls.
In a full skin defect model in nude mice, VEGF levels were significantly increased compared to controls in VEGF gene activated scaffolds 14 d after implantation, but not in skin from the wound edge.
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Mesenchymal stem cells seeded in each layer of the bilayered gene- activated osteochondral scaffold showed significant cell proliferation, high expression of TGF-β1 protein and BMP-2 protein respectively.
In the current study, we have used gene activation in a well-characterized, continuous human cell line to produce gene-activated human acid-β-glucocerebrosidase (velaglucerase alfa).
We have applied engineered transcriptional repressors to specifically inhibit disease gene-activated pathways in oncogenesis.
For nonviral vector, gene-activated matrices (GAM) and ex vivo procedure are usually used to improve the in vivo effect.
Results indicated that HPLCs showed much better proliferation properties on the gene-activated scaffolds than on the pure coral scaffolds, and the expression of PDGFB and type-I collagen up-regulated in gene-activated scaffold.
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