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ETV4 is known to bind to the enhancer of the adenovirus E1A gene, activate matrix metalloproteinase genes and be associated with invasion and metastasis of tumour cells.
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When this gene activates, it targets key muscle proteins for destruction.
Why on earth would any person want this gene activated by a drug?
Li Y, Deng H, Lv L, Zhang C, Qian L, Xiao J. et al. The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer.
Collagen has broad utility as gene activated matrices, capable of delivering large quantities of DNA in a direct, localized manner.
The Bph14 gene activates salicylic acid signaling pathway and induces callose deposition in phloem tissue that inhibits BPH feeding on the host plant (Du et al. 2009).
When cells are infected with SFV, the viral tas gene activates the β-gal gene.
Interestingly, p53 binds a p53-responsive element in the huntingtin gene activating its transcription [ 29].
GIST constitute a distinct STS subtype, ~80% of which carry KIT gene activating mutations [ 35].
A similar model likely applies to MLL and other gene activating complexes as well.
One gene activated by the Foxc1 protein encodes another protein called SDF1-alpha.
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