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Wistuba, I. I. et al. Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma.
There are several hundred known gene abnormalities of differing types that are causally related to ASDs.
Prognosis varies with each phenotype and among gene abnormalities; those involving MCP are associated with the best prognosis.
But isolating and understanding specific gene abnormalities is challenging with diploid cells because they typically have a copy that is normal and serves as a backup.
Complex physiological interactions determine the functional consequences of gene abnormalities and make mechanistic interpretation of phenotypes extremely difficult.
A relatively small number of these gene abnormalities, if present in a developing child, incur great risk for the condition.
Specific gene abnormalities already have been isolated in families with an unusual number of cases.
These findings suggest that activation of β-catenin signaling, probably secondary to the gene abnormalities, plays an important role in the formation of the complex epithelial architecture in APAs, leading to inhibition of cell proliferation through overexpression of p21waf1.
They sequenced her tumor against known cancer gene abnormalities – but didn't find any.
All of these lead to cell death, gene abnormalities and cancer [4].
However, a few arms address more common gene abnormalities and for those the goal is to enroll 70 patients per treatment arm.
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